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If you need Zetia discount coupons – you came to right place! First of all, let’s talk about this pill. Zetia is representative of a class of lipid-lowering drugs. It is based on the active substance - Ezetimibe. It prevents the absorption of cholesterol, decreases the flow from the intestine to the liver and increases the excretion of cholesterol.
Ezetrol is used to lower high levels of blood plasma cholesterol.
It is prescribed for the following conditions:
- primary hypercholesterolemia
- homozygous familial hypercholesterolemia.
Good effect can be achieved, while the use with a statin and a rigid diet. There are very little reviews of Zetia on the Internet; the main reason of it is that it is a new drug. From the limited comments we can understood that the drug has a good effect.
The maximum lipid-lowering effect of this drug develops after 2 weeks of use. Its pharmacokinetics is independent of the age, gender, renal or hepatic function. However, given the lack of data on the safety of prolonged use of this drug, Zetia is not recommended in patients with moderate or severe liver disease.
Patient says: This drug has been assigned to me in conjunction with a rigid diet. I feared that there would be significant side effects, as in the previous preparation I got side effects where very serious. Ezetimibe was appointed to replace it. It turned out that the drug is working properly, cholesterol began to decrease rapidly, but not without side effects. Among them where diarrhea, rash, headache - although some friends of mine take him, and they have no side effects.
Some patients find that the price of drugs is too high. This is the reason to buy generic version of Zetia and purchase meds with the discount provided you by our Zetia coupons.
Controversial clinical Zetia trials
The testing of the preparation made from ezetimibe and simvastatin mixture was conducted to show that Ezetimibe can reduce the growth of fatty plaques in the arteries. Instead, by the results of the test in 2008, it was reported that "it was not observed for changes" in arterial plaques in the application of Zetia. Scientists from the American College of Cardiology (ACC) argue that Ezetimibe can be used in patients who can not tolerate statins or who do not help even high statin dosages. The primary endpoint is the treatment of hypercholesterolemia prevention of cardiovascular side effects, such as death from cardiovascular disease. Although ENHANCE test were not found significant differences in mortality was measured by the difference in the thickness of the artery (femoral and carotid intima-media) for detecting the amount of reducing atherosclerotic plaques. After two years, there was found no significant differences in the thickness of the arteries in patients receiving simvastatin and Ezetimibe and in patients taking simvastatin alone.
Since the test has not been shown ENHANCE that Ezetimibe any way affect the reduction of cardiovascular diseases, of atherosclerosis or mortality, despite the reduction in LDL, doctors attempted to determine whether to use the drug in some other way. They also concluded that the reduction of LDL are not always associated with a reduced risk of atherosclerosis. ENHANCE Reviewers felt that Ezetimibe acts short period of time. Moreover, many patients for a long time already taking statins, so that the thickness of the artery have been reduced. Perhaps if they did not use statins, ezetimibe, could have a greater effect. The findings provoked conducting three large outcomes of clinical trials. The test ARBITER 6-HALTS included patients with ischemic heart disease, or with equivalent risks such as diabetes, are already taking statins. They were randomly assigned to groups receiving either further extended release niacin or ezetimibe, and the primary endpoint was the change in the thickness of the artery wall. Both drugs cause a decrease in cholesterol of low density lipoproteins. Nicotinic acid reduces the thickness of the walls of the arteries, but Ezetimibe paradoxically increases the thickness of the artery wall. Patients taking ezetimibe, also have been exposed to more serious cardiovascular risks. The trial was terminated early after 208 volunteers completed the study.
Other studies are expected in the next few years. Even before the completion of the ARBITER 6-HALTS, March 30, 2008, as a result of the meeting of the ACC in the press there was negative information with regards to drugs such as of Zetia, when Yale University cardiologist Harlan Krumholtz and agree with them colleagues have questioned the effectiveness of such drugs. Krumholtz argued that these drugs should not be the first or even second choice for a doctor's appointment. Final conclusions about the efficacy and safety of Zetia can be made when the results will be available more significant and complex tests. In 2011, was performed the SHARP trial, which compared the combination of simvastatin and ezetimibe and placebo in 9000 patients with chronic kidney disease. This trial showed a reduction in cardiovascular risk when taking the combination drug, but an increase in total mortality due to increased mortality not related to cardiovascular failure from unknown reasons that outweighed the decline in mortality in the result cardiovascular risk in this group of patients. Test IMPROVE-IT, which compared the combination of simvastatin and Ezetimibe + simvastatin alone in 18,000 patients are estimated to be completed in 2014.
The results of the application of Simvastatin and Ezetimibe in Aortic Stenosis study showed a possible increased risk of cancer due to the combined use of these drugs. The actual role of such a discovery yet to be determined. Ezetimibe + Simvastatin test results were more favorable than that of ezetimibe alone. 2010 Research has shown that this combination was more effective in reducing lipid levels than alternative means and atorvastatin.
There where not conducted adequate and well-controlled studies of the safety of the medication during pregnancy, therefore the use in these patients is not recommended. In the event of pregnancy should stop taking Zetia.
Doctors say that Ezetimibe prevents the formation of biliary cholesterol stones and restore contractile function of the gallbladder. This modern medicine should be popular in the near future, because drugs based on Ezetimibe are widely distributed in the United States.
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